Giulina Rancic can’t seem to catch a break. The reality TV star and her husband were dealt another serious blow in their quest to have a bigger family when their surrogate miscarried for the second time.

The fact that this was the couple’s last embryo made it even more painful, something that Rancic acknowledged in an interview with People Magazine. She also said that “We were so optimistic with this last embryo” and thought that “This is definitely going to work. This is our last shot.”

The petite star and her husband, businessman Bill Rancic, have always wanted to add another child to their family. Their son Duke, now 2 years old, was also born via surrogate.

The couple had 3 more embryos remaining and decided to try for another child using the same surrogate. She miscarried after successfully being implanted with 2 embryos last year. Their final attempt with the last remaining embryo ended on New Year’s Eve when the surrogate suffered another miscarriage.

Giuliana Rancic devastated after surrogate miscarries for second time http://t.co/Su5FfGqYUl pic.twitter.com/19n2aODTeQ

— Daily Mail Celebrity (@DailyMailCeleb) April 1, 2015

Rancic’s grueling journey to get pregnant has been seen in detail in her TV show. Sadly, the TV host can’t get pregnant herself as she is taking cancer-suppressing medication after a breast cancer diagnosis in 2011 and a double mastectomy.

Despite these setbacks, Rancic is still optimistic and determined. She and her husband are now considering adoption as a way to have another child.

“I think adoption is a beautiful gift you’re giving each other,” Rancic said in an interview. She also admits that she’s more comfortable with the idea of adopting now – “Because I think to myself, ‘I love Duke so much, if I couldn’t take care of him, I hope there would be someone else who would love him.’”

Giulina Rancic is admirably also keeping things in perspective, confiding to Life & Style that “If I don’t ever have another kid, I have to remind myself that I’m very fortunate to have what I have.”