Multiple Sclerosis ‘Immune Exchange’ Discovered

    November 20, 2012
    Sean Patterson
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A new study has identified and “immune exchange” that allows disease-causing cells in patients with multiple sclerosis to move in and out of the brain. Researchers state that this exchange may be the key to better treatments and diagnostics in the future.

According to the study’s authors, one current theory on multiple sclerosis holds that self-reactive B cells in the brain activate and cause inflammation. The exchange of B cells uncovered by the new study could mean that the B cells are “accessible” when moving from the brain.

“The hope is that if we can identify culprit B cells, using precise tools, we will be able to better diagnose multiple sclerosis and monitor disease activity,” said Dr. Hans Christian von Büdingen, lead author of the study and neurologist at the University of California at San Francisco (UCSF). “In addition, in ways that may have to be tailored for each patient, this may also allow us to develop therapies that directly target disease-causing B cells.”

The study, published this week in the Journal of Clinical Investigation, obtained DNA sequences from multiple sclerosis patients at the UCSF Medical Center. Since 2008, two UCSF clinical trials have shown that blocking B cells may stop multiple sclerosis flare-ups from occurring. Büdingen and his colleagues hope their new findings will lead to a “precision strategy” where treatments can be tailored to the exact identity of the culprit B cells in a particular patient.


    MS should of been cured many years ago. Too many are making money out of this disease and too many have cosy relationships with pharmas making trillions of pounds also tahts why CCSVI is being denied too


      thats why sorry for spellings

  • Speedy

    I agree with you, Lynn! Gilenya and other MS medicines have made a billions off of us. Why should they find a cure?? No one wants to LOSE money. It’s sad.

  • Arlon r long sr

    Im so hart broken to hear what is happening to the pepole living with M.S. But i wont give up! been waiting for 20years for a cure, gess i will wate for a nother 20 years, but i wont give up!

  • Cesar Gonzalez Madrigal

    My dad has MS and he says the shots are getting unbearable. If someone knows about alternative medication please let me know.

    • Blindhelix

      Cesar – I’ve been on Tysabri (Natalizumab) for two years and four months, diagnosed with MS in 2002, and have been through seven years of Rebif and one of Copaxone. I haven’t had a major relapse in almost two years. The downside is the 1/500 (after two years) risk of developing progressive multifocal encephalopathy, which is almost invariably fatal, but the benefits have been amazing for me. One infusion every four weeks, no daily injections. Best decision I ever made. And if it kills me, at least I’ll have had these two good years.

  • Savfta

    How will stem cell treatment affect this exchange?