Giuliana Rancic had a well-documented struggle with getting pregnant; it was the subject of many episodes of her reality show, “Giuliana and Bill”, which showcased the E! host’s life with her husband. After several invasive rounds of IVF–In Vitro Fertilization–Giuliana was told she had to have a mammogram done as part of the treatment. If it hadn’t been for the couple’s struggles to conceive their son, Duke, she might not have known she had breast cancer until it was too late.

“Technically this baby saved her life because had she not gone through IVF — the doctor made it mandatory that she get a mammogram — they would have never found what they found so we owe this little guy debt of gratitude and I’m sure he’ll never let you forget it!” Bill said.

Despite their struggles to conceive and all the pain that came with it, the couple say they definitely want to try it again.

“We’re definitely thinking about it,” Giuliana said. “We’d love another child. So, we’ll see. I’m like, ‘Bill, I’m Italian, I need a big family.’ I mean, there’s nothing more beautiful. I think [you should] have as many kids as you can handle!”

Rancic had to undergo a double mastectomy in 2011 to save her life, but is in good health these days. She says Bill was the main factor in getting through it.

“I feel so bad when I meet a woman who doesn’t have a husband or a boyfriend or someone that can take care of her…I don’t know how they do it,” she said. “More than anything, yes, [Bill] was at all the doctor’s appointments, but where I really needed Bill was at 2 o’clock in the morning when I would wake up sweating and crying and just devastated. That’s where I needed Bill to calm me down and talk me off the ledge. I wish there was a way I could be with these women, in the middle of the night when they wake up like that, because that’s the scariest thing. That’s why I always say to friends of women going through breast cancer, try to sleep over, try to be there, ‘cause that’s when you really need someone — in the middle of the night when you just wake up and your just like, ‘What the hell is going on?’”