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Multiple Sclerosis Drug ‘Reboots’ the Immune System

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[ Science]

New trials show that a cancer drug can be an effective treatment for multiple sclerosis (MS) by ‘rebooting’ patients’ immune systems. The results of two phase III clinical trials were published today in the journal The Lancet.

The trials, sponsored by Genzyme and Bayer Schering Pharma, found that for patients who recently relapsed, using a drug called alemtuzumab saw new episodes reduced by 49% over standard treatment and 65% of them remained relapse free compared to 47% of those on standard MS treatments. In addition, alemtuzumab was found to reduce the risk of acquiring disability by 42% over standard treatments.

“Our research shows the transformative effect that alemtuzumab can have for people with MS,” said Alastair Coompston, principal investigator on both studies and professor at the University of Cambridge. “Patients who continue to show disease activity while on their initial therapy are especially difficult to treat. Now, we have shown that alemtuzumab works where first-line drugs have already failed. It not only reduces the chances of disability associated with MS but may even result in long-term clinical improvements.”

The CARE MS II trial looked at 840 MS patients who had previously been treated but relapsed during therapy. They received either alemtuzumab or interferon beta-1a treatments. They had check-ups every three months for two years and yearly brain scans.

The CARE MS I trial looked at 581 patients who were not previously treated for MS. As in the other trial, the patients received either alemtuzumab or interferon beta-1a treatments and were monitored for two years. It found that alemtuzumab reduced MS relapses 55% over the standard treatment.

“Although alemtuzumab causes potentially serious side-effects, these can be identified and treated provided a monitoring schedule is carefully followed,” said Dr. Alasdair Coles, lead author of the study based on the trials and a clinician at the University of Cambridge. “Additionally, we think that we can identify which patients are at risk of autoimmune disease after alemtuzumab, and we are currently recruiting for a clinical trial which will explore whether we can use a drug to reduce the risk of autoimmunity in those at highest risk.”

Multiple Sclerosis Drug ‘Reboots’ the Immune System
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  • http://webpronews John Lucas

    Please send me information on the MS drug alemtuzumab.

    Thank You.

  • Debbie Scheuss

    Please Send Me Info On This New Treatment Drug.

  • K M

    Please send me information too

  • Cheryl Brewster

    Please send it to me also!!!

  • Terry Bruno

    Please send me more information also, any responses of people who have tried alemtuzumab For M.S. therapy.

    Thank You

  • Judi K

    please send me information on the MS drug alemtuzumab! Thank you!

  • shirlee bernard

    I would like info sent to me about alemtuzumab. Thank you

  • Ronan

    Could I please be sent information on this drug/MS related studies also?

    Thank you

  • angelica pulliam

    2 of my most beloved nephews been diagnosed w/ms one advance the other first stage could u please send me all info available on this medicine and also if is available in mexico city, thanks!!!

  • JJ

    No need to send me any information. I found all I needed to know by doing an Internet search.

  • Nina

    It is ridiculous that MS research studies only last for 2 years, as many of the individuals in the study may naturally have a phase of remission, regardless of whether they were on a new drug or not; nobody knows for sure whether the drug assisted in a reduction of symptoms. MS studies need to be greater in length to assess efficacy and possible side-effects, before they are delivered to the market. It is obvious that many drug companies are in it for the profit of releasing a new drug early to the market – it’s all about greed and not necessarily about helping patients!

  • http://WebProNews Angie Rodriguez

    This sounds very promising. I disagree with the responder who said that MS studies should take longer. Some people can’t wait any longer. The FDA has strict guidelines before meds can reach the patient anyway. Hurry up with the studies I say…I want to benefit from your knowledge!!!

  • http://yahoo.com nancy

    Please concider doing igenex labs,palo alto,calif!i was misdiagnosed for ms instead of lyme disease!i saw the tick bite on my left ankle in 2001 after many inaccurate hospital test that came neg!and no abx treatment!in 2006 i developed brain lesions from lyme disease!i always said it was lyme but neg test’s stopped me from getting treated!2008 after taking ms drug’s that gave me enchephilitis,which sent me to the er for iv steriods that spread my lyme disease!im now paralized in a wheelchair for 4 years!igenex saved my life!it showed lyme disease and im center of disease control positive!please watch the award winning documentry under our skin!!!!!!!!!!!!!

  • april weston

    please send me information on this promising new drug. Thank you.

  • Raul

    Why does the Medical Field in the Industrial Countries still struggle to find corrective solution for MS, MD and other crippling diseases, and why is it that the Drug companies studies are the ones that go out to the public. I truly doubt that any Drug Company has greater positive and permanent result than the results I have with my patients. Go figure!

  • Rogue Roger

    Please people, refrain from doing all these unnecessary drugs. You are only contaminating your bodies and going deeper in your maladies. The truth about MS and most other Autoimmune diseases, which the Pharm and drug companies don’t tell you and don’t want you to know is that they are mainly caused and further propagated by over-contaminating your bodies with the different types of Toxins available all around us today. Our immune systems are designes to ward off or adjust our bodies to adapt to the normal levels of Toxins available everywhere (The Air, Water/drinks, Food, Drugs/Medicine, etc.), but when our bodies are exposed to extreme levels of Toxins (as is the case for those living in large metropolitan and industrial cities) the defense system (Autoimmune system) goes into a shock and start acting in an unnatural way which many in the medical field have labelled Multiple Sclerosis and other Autoimmune system diseases. Please try the Nautural approach. It is the only thing that works. It is the only solution since it reverses the contamination process and reduces the levels of Toxins in your bodies. By reducing the Toxins you are halting or slowing the further relapses and stopping the attacks. Granted that the damage already done cannot be reversed (no one but God can reverse that) but at leat no, or very little further damage will take place. Search for Dr. Terry Wahls (an MS patient herself) or watch “TEDxIowaCity – Dr. Terry Wahls – Minding Your Mitochondria” on youtube.

    • jb

      Do you have ms?

      • Rogue Roger

        Wow. Get a hold of yourselves guys. First of all you don’t have to have MS to KNOW about MS. Many of those in the research field and the medical profession don’t have MS yet I bet you ll give them a listen when they talk. And for that matter I have lived with MS for the past 7 years. My wife was diagnosed with that disease 7 years ago and I have been her companion in her struggle with MS ever since. We have gone through treatment after treatment and like Andrea here tried the drug as well as the holistic approach. Don’t misunderstand me, I am not coercing anyone to do anything they do not wish to do. All I am saying is that there people in the medical field who have MS themselves that are trying to clean their lives by detoxing their environment with starking results and remarkable improvements. Summation: Do not take mine or anyone’s word for it, search for Dr. Terry Wahls and listen to her. She’s both a doctor and an MS patient. I think that will fit your bill.

    • Andrea Henley

      Do YOU have MS? If not, then shut up. I DO have MS and have for 13 years now. Have tried EVERYTHING from the natural approach to all the drugs. What may work for one person, doesn’t work for the next. You obviously have no clue what you are speaking about and for you to make judgments against anyone, whether they are on drugs or the natural approach is just being a complete idiot. Let me know when you are diagnosed with a disease such as this, and then I’ll take the time to listen to your lack of opinion further.

      • Rogue Roger

        Lady with a big chip on her shoulder, just look up Dr. Terry Wahls and don’t worry, you don’t have to thank me. I know it rubs against your grain.

  • Tish

    The clinical trials were rushed for Tysabri and it was pulled off market after people died. That is reason for clinical trials! I have MS and have been on every therapy that is out there. The ABC interferons along with Rebif. Then to Tysabri! Stayed in remission for 12 years until was under a great deal of stress! And came in and out of remission on all of the above meds! Vitamin D deficiency appears to be problem so Canada gives higher levels vitamin D. Lately I get massage, acupuncture, take Vitamin D, meditate, do yoga, and do my best to sleep well. I don’t know what this medicine is but have also seen reports that certain chemicals in medical marijuana work for MS and keeps cancer from mestatisizing! Saw some limited information on the National Multiple Sclerosis Society site with concerns for memory impairment and concentration along with a concern that patient’s would be high. I do not know what the final answer will be for MS but pharmaceutical companies you best believe are hoping to get very rich as a result! Tysabri treatments cost 8,000 dollars each treatment along with money for MRIs , blood work, office visits have to pay out to stay on it!

  • KJ

    Alemtuzumab is Campath!!

  • chris stewart shoals

    please send information to me concerning the new drugs “Alemtuzumab”
    and p-40 concerning M S
    Thank you
    Chris Stewart

  • lisa henderson

    I’m 37 had ms for 20yr and I’m pleased to say I’m starting this new drug in January 2013 ,
    Iv never been given the chance of any drug till now,let’s hope it helps us all xx

  • Roger dodger

    To all you tools who say “send me info,” look it up for yourselves. Praise be the lord.

  • robert

    I would love to recieve information on this study and other new ones.