Ariana Grande paid tribute to her late grandfather Friday at this year’s Stand Up to Cancer telethon.

The 21-year-old songstress gave a moving performance of her song, My Everything, for her beloved grandfather, who died in July following a lengthy battle with cancer.

“Supporting a cause that is near & dear to my heart. tonight I’m singing for grandps! i miss u,” Grande tweeted before taking the stage Friday at the Los Angeles event.

The telethon, which was broadcast to dozens of broadcast and cable networks, also featured performances by The Dave Matthews Band, The Who, Jennifer Hudson, Lupe Fiasco, and Common.

supporting a cause that is near & dear to my heart. tonight I'm singing for grandps! i miss u #StandUpToCancer @su2c http://t.co/F2reRZG4dt

— Ariana Grande (@ArianaGrande) September 5, 2014

thank u for having me & for the work u do “@SU2C: We stand up with @ArianaGrande & her beloved grandfather who she recently lost to cancer"

— Ariana Grande (@ArianaGrande) September 6, 2014

It was obviously a difficult performance to get through for the worldwide singing sensation.

thank u for having me & for the work u do “@SU2C: We stand up with @ArianaGrande & her beloved grandfather who she recently lost to cancer"

— Ariana Grande (@ArianaGrande) September 6, 2014

This was the fourth Stand Up to Cancer telethon, which raises money to support research for new cancer treatments. Gwyneth Paltrow and Joel Gallen returned to produce this year’s telethon for a second time.

Others on hand for the telethon included Jennifer Aniston, Reese Witherspoon, Jane Lynch, Jesse Tyler, and many more.

Honored to reunite w/ lovely souls, like my sister #JenniferAniston, for @SU2C! Donate: http://t.co/2WL8vjVxyI pic.twitter.com/OnX5NyWp59

— Reese Witherspoon (@RWitherspoon) September 6, 2014

Hollywood stands up to cancer: see all the red carpet arrivals at the #SU2C telecast! http://t.co/2jArI9vAfA pic.twitter.com/9YmUaVY3fa

— E! Online (@eonline) September 6, 2014

See @janemarielynch & @GwynethPaltrow! MT @FOXTV Tonight! Tune in to @SU2C at 8/7c. The stars will be there! #SU2C pic.twitter.com/quu3uDzvBn

— GLEE (@GLEEonFOX) September 5, 2014