"For the sake of their children, they ask for respect and privacy as they navigate this time in their lives," the Rizzoli & Isles star's rep told the publication exclusively.
The couple, who got engaged in 1998 while making an appearance on The Tonight Show with Jay Leno and later married in 2001, have three daughters- Finley, 11, Avery, 9, and Emery, 5.
In February, Harmon explained to CBS News how hard it is to manage her time between filming Rizzoli & Isles and spending time with her family. Her family currently lives in Charlotte, North Carolina, and filming takes place in Los Angeles.
"I shoot six months out of the year," Harmon said. "So I'm on the other side of the country for six months out of the year."
Actress Angie Harmon and former NFL pro Jason Sehorn are separating after 13 yrs. of marriage. http://t.co/7bih9YS59d
— EntertainmentTonight (@etnow) November 3, 2014
"The silver lining in this is that I'm from Texas. They get on a plane from Charlotte, I get on a plane from LA. We fly, we meet in the middle." Harmon added. "They get to spend time with their grandparents and grow up with their cousins. It's not the ideal situation, but it works. It really really does."