I think with the defaults it should be ok, because they are pretty standard fonts.
Google Tweaks AdSense Fonts for Better Performance
Announces New Default Fonts for Specific Ad UnitsGoogle is updating the default font faces associated with specific AdSense ad formats. The decision to do so is based on findings that different fonts perform better with different formats.
"In the same way that you regularly try out changes to your AdSense ads to increase your earnings, we're also constantly looking for new ways to help you earn more," explains Arlene Lee of Google's Inside AdSense Team. "We've been analyzing the performance of the three available font faces (Arial, Verdana, and Times New Roman), and have found that each font performs best in different ad formats due to factors like character width."

The changes will only apply to ad units that have "AdSense Default" selected as the font face, and are in languages that have Latin-based characters like:
- Croatian
- Czech
- Danish
- Dutch
- English (US and UK)
- Finnish
- French
- German
- Hungarian
- Indonesian
- Italian
- Norwegian
- Polish
- Portuguese
- Romanian
- Slovak
- Spanish
- Swedish
- Turkish
AdSense ad units are mostly set to Arial as the default, but a few are in the Verdana font. The new defaults Google is launching include the following:
Arial: 728x90, 336x280, 120x600, 120x240
Verdana: 300x250, 160x600, 468x60, 250x250, 234x60, 125x125, 180x150
Times New Roman: 200x200
While Google is changing the defaults, the company still encourages users to experiment with fonts on their own. There is no reason why other fonts might work better for your own ads.
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I think font change will
I think font change will make a big difference but the problem is if the persons browser does not support the fonts also could this cause problems with page search preformance.