Google Sites was powered by everybody’s go-to for all things online video, YouTube, to claim the highest ranking with 161 million unique viewers and reached a record high of 20.9 billion videos viewed. Facebook came in at a distant second rank with 59.8 million viewers and the bronze ranking went to VEVO with 57 million. Microsoft Sites and Viacom Digital followed with 49.1 million and 48.2 million, respectively.

With more than 42 billion videos viewed during the month, the firm reports that the average viewer watched a record 21.1 hours. Since comScore defines the average online video time as 5.5 minutes, that works out to roughly about 229 videos per user. That’s a lot of cat videos people watched last month.

As far as video ads go, Americans watched 7.5 billion ads in October, which totaled more than 3 billion minutes. Hulu generated the highest number of video ad impressions at more than 1.3 billion. Tremor Video ranked second overall and crossed the milestone of 1 billion ads viewed for the first time. BrightRoll Video Network ranked third with 756 million ads, followed by Specific Media with 512 million and CBS Interactive with 415 million.

comScore also ranked Youtube Partner Channels in October, revealing that VEVO entertained 54.2 million viewers to capture first place. Warner Music maintained the second-place rank with 30.4 million viewers. Gaming channel Machinima ranked third with 17.7 million viewers followed by Schmooru with 9.9 million viewers.

People familiar with Amazon’s Kindle electronic book reader will see something familiar when Esquire rolls off the presses with its October issue.

Through a deal with E Ink, and the participation of Ford Motors, Esquire’s 75th Anniversary stands to arrive with a paper cover, powered by a battery, featuring the kind of technology once imagined only in Jetsons cartoons. E Ink’s technology is used in Amazon’s Kindle and other e-book readers.

E Ink said Esquire and its publisher, Hearst, approached the company in the summer of 2007 to work on an electronic paper concept that would be suitable for a print magazine. The new opportunity needed to overcome several challenges, but is now on schedule for debut.

Ford will be the big beneficiary of the buzz behind Esquire’s printing and E Ink’s technology. The auto maker plans to debut its Flex Crossover inside the whiz-bang electronic paper cover of Esquire, in a double-page advertisement.

Esquire plans to take a forward look at the 21st Century from the platform of their electronic paper magazine. Among the ideas we wonder if they will consider, beyond yet another Angelina Jolie cover: making e-paper capable of receiving and displaying Internet content delivered wirelessly.