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One of the key problems bots represent to Twitter is that they might make the data nearly unusable for meaningful data mining. Companies start looking at Twitter now for sereous reserach and if there's too much junk in the system produced by bots, the exercise may become pointless. That said, this risk certainly can be mitigated on Twitter's side with more investments into protection. More at Twitter Wars: Episode II - Attack of the Twones

I always check out the @johnkremer posts because they are often very interesting and personally directed to me. I much prefer @johnkremer replies to DMs because it's so much easier to engage in a conversation and track the relationship.

DMs actually include more spam than @johnkremer replies. I just delete the spam messages. Not a problem now. If someone abuses DMs, I unfollow them.

So I don't see spam as being a big issue on Twitter.com.

Thank you so much Chris for keeping us informed
and up-to-date about the latest trends when it comes
to Twitter and Spamming. I agree with you totally!

I personally use Twitter for talking about common things
that I am doing and on occassion, I will promote my eBay
Design and Marketing Agency. I really do not like it all
when I see 10 tweets in a row from someone because
that does appear to be a little extreme and does look
bad like you had mentioned.

I think Tweeting in moderation whether it is for
commerical use or personal use is perfectly fine.=)

I am an eBay Powerseller and specialize in
Search Engine Optimization Strategies and have been
offering my Marketing Services on eBay since 2006.
I also custom design websites and eBay Stores!

If anyone needs Custom Website Designs or
Internet Marketing, please come and see me! =)

Sincerely,
Tonya's Dynamic Designs

I really hate the one who post 100's of Tweets a day many within a second of each other. I unfollow these, there has never been a need to block them. Most of these span tweets have the oo for an avitar. Other span comes in the form of repeated sales pitches with links to websites with no conversation from a real person. Unfollow takes care of them too. The anoying celebrities that follow no one back but hog Twitter and slow down everone else's action is not what we go to Twitter for. Most of us want a two way relationship on Twitter. Is this a new celerbraty hogging of Twitter a form of Spam?

I just started using Twitter for one of my sites, its delicate balance trying to find followers, promote our site but also be contribute value or entertaining information.

I try to include personal commentary, dialog specific to my niche as well as sit updates.

I have seen tonnes of spam in the few days I have had an account and I can see how its completely useless to do so be cause I just ignore tweets from those people and soon will be unfollowing them once I get a better grasp on what I feel are best practices

I agree with you completly. People don't abondon their emails because of spam. But people can abondon their email accounts because of spam. So, same thing can happen with twitter. Also, twitter always described as a new marketing venue. So, people use it for spamming, same as email.