Lung Cancer Treatment Resistance Reversed in New Study

By: Sean Patterson - June 10, 2014

Lung cancer patients got some good news this week as a new study has shown how doctors might reverse genetic resistance to a common lung cancer drug.

According to the study’s authors, around 40% of lung cancer patients are resistant to a specific targeted therapy drug known as erlotinib. The drug is an EGFR inhibitor and the therapy is meant to block non-small cell lung carcinoma tumors from growing.

The new study, published in the Journal of Clinical Investigation, showed that the over-expression of the Cripto-1 protein in patients could be what is making them resistant to the drug. Researchers demonstrated that blocking Cripto-1 signaling transduction in animals restored the ability of erlotinib to act on lung cancer cells. This blocking was accomplished using an Src inhibitor.

“This is a welcome finding because Cripto-1 belongs to a family of proteins that can be targeted by drugs that have already been developed,” Dr. Giuseppe Giaccone, senior investigator on the study and an associate director for clinical research at Georgetown University’s Lombardi Comprehensive Cancer Center. “Most patients using erlotinib exhibit either intrinsic or acquired resistance, so we frankly don’t cure anyone with the drug, although we can extend lifespan. So if we can understand what is limiting the activity of the drug up front, I believe treatment of patients can be vastly improved.”

Giaccone and his colleagues are currently setting up a clinical trial to test the method on human lung cancer patients. Though the specific Src inhibitor used in the study is no longer an option, the researchers say they will use the Src inhibitor AZD0424 in combination with erlotinib during the trial. Patients selected for the trial will have non-small cell lung cancer and have cancer cells with an EGFR mutation. Previous research has found these types of patients to be most sensitive to erlotinib.

“There has been very little investigation when a person never responds to an EGFR inhibitor – most research has been done on acquired resistance that occurs after the drug has shown some benefit,” said Giaccone.

Image via Thinkstock

About the Author

Sean PattersonSean is a staff writer for WebProNews. Follow Sean on Google+: +Sean Patterson and Twitter: @St_Patt

View all posts by Sean Patterson
  • John Williams

    I use to Have cancer of the lungs, i am very amazed and happy about the healing Dr Ariba gave to me from the help of his ancient herbs
    if you have any question for me concerning all i have said email me at: milliamsjohn@gmail.com But if you feel like contacting Dr Ariba at once you can email him now for your own healing too at: dr.aribaspelltemple@outlook.com Or draribaspelltemple@gmail.com for direct contact good luck

    i am John.

  • John Williams

    I use to Have cancer of the lungs, i am very amazed and happy about the healing Dr Ariba gave to me from the help of his ancient herbs
    if you have any question for me concerning all i have said email me at: milliamsjohn@gmail.com But if you feel like contacting Dr Ariba at once you can email him now for your own healing too at: dr.aribaspelltemple@outlook.com Or draribaspelltemple@gmail.com for direct contact good luck

    i am John…….

  • Alabi Ojo

    Dr. ARIBA Miracle Oil
    Why go the expensive treatment in hospitals whereby Marijuana/Cannabis oil is here to clean you from cancer and many more illnesses …No prescription/license needed
    Dr. Ariba Cannabis Oil is the answer

    All forms of disease and conditions are treatable and often curable with the use of high grade hemp oil as a treatment
    We offer top quality Dr. Ariba/Medicinal Marijuana/Cannabis oil,we supply to dispensaries and individual patients who are 18 years and above
    Do NOT let your family member suffer from cancer and many more when we are at your service
    Cure for Cancer and Other Conditions
    Dr. Ariba CBD-oil has been used to cure the following ailments:
    • Cancer(All Types)
    • Arthritis
    • Diabetes and HIV/AIDS
    • Leukemia
    • Osteoporosis
    • Crohn’s Disease
    • Insomnia
    • Migraines
    • Depression
    • Asthma
    • Multiple Sclerosis
    • Psoriasis
    • Glaucoma
    • Burns
    • Chronic pain
    • Mutated cells (tumors, polyps, warts)
    • High blood Pressure(Hypertension)

    Anti-Aging Properties
    In addition to its effectiveness in treating cancer and numerous conditions, Dr. ARIBA cannabis oil also has marvelous anti-aging properties…………The hemp oil rejuvenates your vital organs which deteriorate over time.
    So the oil will make you feel a couple of decades younger.
    We also offer discreet shipping and delivery is in no time.
    The Herbal Meds we supply will help you solve all your pains problems.
    If you have are looking for treatment for any of these conditions, Email draribaspelltemple@gmail.com or dr.aribaspelltemple@outlook.com
    DR. ARIBA HEALING HOME NIGERIA….