The first YouTube mashup that successfully and hilariously reframed a classic film/TV show to fit a different style that I remember seeing was called "Shining," and it used clever editing and a certain Peter Gabriel song to make the classic horror film look like a family comedy.
Ever since, I've loved this sort of thing. With the right music and editing, you can transform any piece of media into something completely different.
Take for instance this new trailer for Breaking Bad that re-imagines it as a mid-90s sitcom. It's wonderful.YouTube]